Abstract: Mapping Current Densities in the Brain with Transcranial Acoustoelectric Imaging

Abstract: Mapping Current Densities in the Brain with Transcranial Acoustoelectric Imaging

Acoustoelectric Imaging (AEI) is a disruptive technology that exploits an ultrasound (US) beam to transiently interact with physiologic or artificial currents, producing a radiofrequency signature detected by one or more surface electrodes. By rapidly sweeping the US beam and simultaneously detecting the AE modulations, 4D current density images are generated. When applied to the brain, transcranial acoustoelectric imaging (tABI) overcomes limitations with electroencephalography (EEG), which suffers from poor spatial resolution and inaccuracies due to blurring of electrical signals as they pass through the brain and skull, and, unlike fMRI and PET that measure slow metabolic signals, tABI directly maps fast time-varying current within a defined brain volume at the mm and ms scales. This presentation will describe the underlying physics and mathematics of tABI, recent progress and challenges using numerical simulations and bench-top models, and its potential impact as a cutting-edge noninvasive modality for fast and accurate electrical brain mapping in humans.