Geologic CO2 sequestration sites usually have large uncertainty in geological properties, such as uncertainty in permeability and porosity fields. Geological uncertainty leads to significant uncertainty in predicted risk metrics such as CO2 plume extent, CO2/brine leakage rates through wellbores, and impacts to drinking water quality in groundwater aquifers due to CO2/brine leakage, all of which will impact the approach for post injection site care (PISC). Pre-injection risk assessment can be used to quantify the amount of uncertainty in different predicted risk metrics. However, it cannot account for the potential value of monitoring data (e.g., CO2 saturation and pressure measurements) acquired during the operation of CO2 storage. In this study, we demonstrate how uncertainty in predicted risks can be reduced by performing monitoring data assimilation.